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Submission + - HHS Secretary Kennedy Halts Clinical Trial of New Covid-19 Oral Vaccine (foxnews.com)

As_I_Please writes: From Fox News:

Kennedy issued a 90-day stop-work order on Friday related to the HHS (Health and Human Services) contract with American biotech company Vaxart Inc., which is working to develop a new COVID-19 vaccine that can be taken orally. The stop-work order comes as 10,000 individuals were slated to begin clinical trials on Monday.

As for the reason for the work stoppage, Secretary Kennedy explained:

"While it is crucial that the Department [of] Health and Human Services (HHS) support pandemic preparedness, four years of the Biden administrationÃ(TM)s failed oversight have made it necessary to review agreements for vaccine production, including VaxartÃ(TM)s," Kennedy said in comments provided to Fox News Digital on Tuesday.

"I look forward to working with Vaxart and medical experts to ensure this work produces safe, effective, and fiscal-minded vaccine technology."


Submission + - HHS Secretary Robert F. Kennedy, Jr. Halts Clinical Trial of New Covid-19 Oral V (foxnews.com)

As_I_Please writes: From Fox News:

Kennedy issued a 90-day stop-work order on Friday related to the HHS (Health and Human Services) contract with American biotech company Vaxart Inc., which is working to develop a new COVID-19 vaccine that can be taken orally. The stop-work order comes as 10,000 individuals were slated to begin clinical trials on Monday.

As for the reason for the work stoppage, Secretary Kennedy explained:

"While it is crucial that the Department [of] Health and Human Services (HHS) support pandemic preparedness, four years of the Biden administrationâ(TM)s failed oversight have made it necessary to review agreements for vaccine production, including Vaxartâ(TM)s," Kennedy said in comments provided to Fox News Digital on Tuesday.

"I look forward to working with Vaxart and medical experts to ensure this work produces safe, effective, and fiscal-minded vaccine technology."


Comment Re:Not a singularity? (Score 5, Informative) 163

According to the second paper linked in the summary, there are theoretical models of black holes that do not feature singularities. The solutions to Einstein's general relativity equations that feature singularities--like Schwarzchild (spherical, non-rotating) and Kerr (rotating) black holes--require space to be flat far away from them. This is incompatible with the universe we live in, which is expanding at an accelerating rate. From the second paper:

Existing models for astrophysical BHs are necessarily provisional. They feature singularities, horizons, and unrealistic boundary conditions (e.g., Visser 2009). Though singularities and horizons are of theoretical interest (e.g., Harlow 2016), the Kerr solution reduces to flat spacetime at spatial infinity. This is incompatible with our universe, which is in concordance with a perturbed Robertson Walker (RW) cosmology to sub-percent precision (e.g., Aghanim et al. 2020; Dodelson & Schmidt 2020). Thus, regardless of singularities and horizons, Kerr is only appropriate for intervals of time short compared to the reciprocal expansion rate of the universe, and can only be consistently interpreted as an approximation to some more general solution.

As for black hole models without singularities

Efforts to construct a BH model in general relativity (GR) with realistic RW boundary conditions have been ongoing for nearly a century, but have met with limited success. Early work by McVittie (1933) generalized the Schwarzschild solution to arbitrary RW spacetimes. Nolan (1993) constructed a non-singular interior for this solution, and progress has been made in understanding its horizon/causal structure (e.g., Kaloper et al. 2010; Lake & Abdelqader 2011; Faraoni et al. 2012; da Silva et al. 2013). Faraoni & Jacques (2007) constructed solutions featuring dynamical phenomena such as horizons that comove with the universe's expansion, evolution of interior energy densities and pressures, and time-varying mass. These solutions are significant, because they show how heuristic application of Birkhoff's theorem in cosmological settings can fail in the presence of strong gravity (see Lemaître 1931; Einstein & Straus 1945; Callan et al. 1965; Peebles 1993). Time-varying mass in particular has been studied by Guariento et al. (2012) and Maciel et al. (2015), but its interpretation remains largely unexplored. All of these solutions, however, are incompatible with Kerr on short timescales because they do not spin. A BH solution that satisfies observational constraints at small and large scales simultaneously has yet to be found.

The measurements described in the paper claim to show that black holes grow and gain mass due to the expansion of the universe without absorbing the mass of stars and gases around them. If this interpretation of their data is true, this may be enough to show that actual black holes do not have singularities.

Cosmologically coupled mass change allows for experimental distinction between singular and non-singular BHs, complementing constraints from short-timescale data (e.g., Sakai et al. 2014; Cardoso et al. 2016; Uchikata et al. 2016; Yunes et al. 2016; Cardoso & Pani 2017; Chirenti 2018; Konoplya et al. 2019; Maggio et al. 2020).

... much further down ...

Our result provides a single-channel explanation for the disparity in SMBH masses between local ellipticals and their 7–10 Gyr antecedents (Farrah et al. 2023). Furthermore, the recovered value of k = 3 is consistent with SMBHs having vacuum energy interiors. Our study thus makes the existence argument for a cosmologically realistic BH solution in GR with a non-singular vacuum energy interior.

Comment Re:Corporate Astrology (Score 3, Insightful) 255

I suppose there might be a darker agenda at work: a desire to hire based on things like gender quotas or other aspects of a person that are actually illegal to include in hiring decisions.

This is exactly what they are doing. If you have 20 rounds of interview, then it becomes much harder to prove they hired based on DIE quotas.

It's far more likely it's the exact opposite. The complicated process creates more opportunities to screen out minorities. Removing indicators of race from resumes results in greater probability for interviews. Bonus points: companies who advertise themselves as pro-diversity discriminate just as much.

Comment Supply and Demand (Score 2) 221

The article points out that as it is, the workforce of low-paid long-haul truckers "tends to turn over entirely every 12 months or so."

"At the moment, the industry is short about 61,000 drivers, according to the American Trucking Associations."

It's amazing how a shortage of goods and services leads to higher prices everywhere except labor. If the industry needs more truckers, have they tried offering more pay?

Comment Re: X-ray optics (Score 5, Interesting) 15

With x-rays this energetic, there are no optics since the rays just go right through anything. But, since the generated x-rays are coherent and are formed in a very narrow beam, you can study the diffraction patterns created after the x-rays pass through the sample.

Here's a great talk about how these light sources work and some of the history and physics: https://youtube.com/watch?v=RK...

Comment Re:Playing the odds. (Score 3, Informative) 181

That's already happening with this drug. From the second linked article:

At the recommendation of an independent Data Monitoring Committee and in consultation with the U.S. Food and Drug Administration (FDA), recruitment into the study is being stopped early due to these positive results. Merck plans to submit an application for Emergency Use Authorization (EUA) to the U.S. FDA as soon as possible based on these findings and plans to submit marketing applications to other regulatory bodies worldwide.

Comment Does $0.001 sound right for a share of PayPal? (Score 5, Informative) 315

Thiel wasn't a savvy investor.

While SEC filings describing that time don’t mention Thiel’s Roth, they show that he bought his first slice of the company in January 1999. Thiel paid $0.001 per share — yes, just a tenth of a penny — for 1.7 million shares. At that price, he was able to buy a large stake for just $1,700.

In 1999, $2,000 was the maximum amount you could put into a Roth in a year.

He purchased shares of his own company that were deliberately undervalued in order to put millions of shares into the Roth IRA account.

Thiel’s unusual stock purchase risked running afoul of rules designed to prevent IRAs from becoming illegal tax shelters. Investors aren’t allowed to buy assets for less than their true value through an IRA. The practice is sometimes known as “stuffing” because it gets around the strict limits imposed by Congress on how much money can be put in a Roth.

PayPal later disclosed details about the early history of the company in an SEC filing before its initial public offering. The filing reveals that Thiel’s founders’ shares were among those the company sold to employees at “below fair value.”

This might be bad situation if the IRS was being deprived of the resources needed to enforce this law such that it was increasingly focusing on poorer families with tax returns that are easier to audit.

What happened a year later?

After 1999, Thiel would never again contribute money to his Roth, tax records show.

He didn’t need to. In just a year’s time, the value of his Roth jumped from $1,664 to $3.8 million — a 227,490% increase.

He manipulated the price of his own company's stock to pay himself extremely well while pretending the stock was worthless for tax purposes.

Comment Re: Gravitational time dilation (Score 1) 33

https://www.nist.gov/news-even...

Described in the Sept. 24 issue of Science,* the difference is much too small for humans to perceive directlyâ"adding up to approximately 90 billionths of a second over a 79-year lifetimeâ"but may provide practical applications in geophysics and other fields.

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